Tevin Coleman rushed for an early touchdown for San Francisco, while Garoppolo was mostly effective despite two turnovers.
Robert Woods rushed for a touchdown on the opening drive for the Rams, who then managed 48 net yards on their next eight drives combined. San Francisco then took control, moving the ball deliberately and thoroughly shutting down the Rams. Everything looked fine for the Rams while McVay called seven consecutive runs on their opening drive.
Malcolm Brown, the longtime backup grabbing a starring role with Gurley out, racked up 40 yards on five carries before Woods scored on a beautifully designed end-around.
Los Angeles then reached the Niners 1 on third down, but ran two straight running plays up the middle for no gain. Henderson, a third-round pick with one career carry before this game, had two impressive runs in the first half — but he dropped a pitchout from Goff on the opening play of the second half, and Arik Armstead recovered at the Rams San Francisco easily scored on the short field.
The Niners again drove to the Los Angeles 2, but Garoppolo overthrew a wide-open Coleman on third down. Rams: LG Joe Noteboom was taken to the locker room on a cart during the first quarter after he injured his right knee.
S John Johnson was ruled out with an injured shoulder in the second half. Gurley missed his first game of the season, as did LB Clay Matthews, their sacks leader. CB Aqib Talib sat out with bruised ribs.
Rams: Visit the Atlanta Falcons on Sunday.
You can watch the live stream of the game on foxsportsgo. Unfortunately, this game could be complicated to see for viewers who have either Dish, or Sling TV, as an ongoing carriage dispute with FOX has resulted in all FOX network channels being removed from those providers with no end to the feud in sight.
They roughed up the Cleveland Browns in Week 5 with tough defense and a big-play offense.
The 49ers ran for yards on the ground against the Browns and are the leading rushing team in the NFL. The 49ers defense, lead by a relentless defensive line, is among the top-five in the NFL in nearly every major statistical category.
Normally reliable kicker Greg Zeurlein missed a yard field goal with 11 seconds remaining and the Rams lost The flip side is the defense has allowed 85 points. You can also get this game on Hulu Live free trial if you prefer that platform and their pricing plans.